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Payers reviewing D62 claims expect estimated blood loss documented in the operative or emergency note, vital sign changes indicating hypovolemia such as tachycardia and hypotension, and a treatment plan involving transfusion or fluid resuscitation

The biofilm matrix acts as a physical barrier to block antifungal penetration, and the sessile fungal cells exhibit metabolic dormancy and upregulated expression of drug efflux pumps and target-modifying genes, and the presence of drug-resistant cells are some of the main factors leading to immune evasion and weakened response to available drugs (Sahoo et al., 2025)

PMID 23695349

doi: 10.1210/jc.2005-1696 26 LiYChenCMaYXiaoJLuoGLiYet al

Its intracellular depletion ultimately results in cell death, and its clinical relevance has been researched for decades